3BZ0

Lactobacillus Casei Thymidylate Synthase Ternary Complex with DUMP and the Phtalimidic Derivative C00

Summary for 3BZ0

Entry DOI	10.2210/pdb3bz0/pdb
Related	1LCE 1TSL 3BNZ 3BYX 3C06 3C0A
Descriptor	Thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-(4-hydroxybiphenyl-3-yl)-4-methyl-1H-isoindole-1,3(2H)-dione, ... (4 entities in total)
Functional Keywords	nucleotide synthase, structure based drug design, methyltransferase, nucleotide biosynthesis, transferase
Biological source	Lactobacillus casei
Cellular location	Cytoplasm: P00469
Total number of polymer chains	1
Total formula weight	37267.98
Authors	Leone, R.,Cancian, L.,Costi, M.P.,Ferrari, S.,Luciani, R.,Mangani, S. (deposition date: 2008-01-17, release date: 2009-01-20, Last modification date: 2023-11-01)
Primary citation	Mangani, S.,Cancian, L.,Leone, R.,Pozzi, C.,Lazzari, S.,Luciani, R.,Ferrari, S.,Costi, M.P. Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening J.Med.Chem., 54:5454-5467, 2011 Cited by PubMed: 21696158 DOI: 10.1021/jm2005018 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation