3BNZ
Crystal structure of Thymidylate Synthase ternary complex with dUMP and 8A inhibitor
Summary for 3BNZ
Entry DOI | 10.2210/pdb3bnz/pdb |
Related | 1LCA |
Descriptor | Thymidylate synthase, PHOSPHATE ION, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, ... (5 entities in total) |
Functional Keywords | thymidylate synthase, methyltransferase, nucleotide biosynthesis, transferase |
Biological source | Lactobacillus casei |
Cellular location | Cytoplasm: P00469 |
Total number of polymer chains | 1 |
Total formula weight | 37295.87 |
Authors | Leone, R.,Cancian, L.,Luciani, R.,Ferrari, S.,Costi, M.P.,Mangani, S. (deposition date: 2007-12-15, release date: 2008-12-16, Last modification date: 2023-11-01) |
Primary citation | Mangani, S.,Cancian, L.,Leone, R.,Pozzi, C.,Lazzari, S.,Luciani, R.,Ferrari, S.,Costi, M.P. Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening J.Med.Chem., 54:5454-5467, 2011 Cited by PubMed: 21696158DOI: 10.1021/jm2005018 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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