3IJZ

Lactobacillus casei Thymidylate Synthase ternary complex with dUMP and Pthalimidic derivative 15C

Summary for 3IJZ

Entry DOI	10.2210/pdb3ijz/pdb
Related	3BNZ 3BYX 3BZ0 3C06 3C0A 3IK0 3IK1
Descriptor	Thymidylate synthase, 2-(4-acetylphenyl)-4-methyl-1H-isoindole-1,3(2H)-dione, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, ... (4 entities in total)
Functional Keywords	transferase, nucleotide synthase, methyltransferase, nucleotide biosynthesis
Biological source	Lactobacillus casei
Cellular location	Cytoplasm: P00469
Total number of polymer chains	1
Total formula weight	37217.93
Authors	Pozzi, C.,Cancian, L.,Leone, R.,Luciani, R.,Ferrari, S.,Mangani, S.,Costi, M.P. (deposition date: 2009-08-05, release date: 2010-08-11, Last modification date: 2023-11-01)
Primary citation	Mangani, S.,Cancian, L.,Leone, R.,Pozzi, C.,Lazzari, S.,Luciani, R.,Ferrari, S.,Costi, M.P. Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening J.Med.Chem., 54:5454-5467, 2011 Cited by PubMed: 21696158 DOI: 10.1021/jm2005018 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.21 Å)

Structure validation