3IH7
Crystal structure of catalytically active human 8-oxoguanine glycosylase distally crosslinked to guanine-containing DNA
Summary for 3IH7
Entry DOI | 10.2210/pdb3ih7/pdb |
Related | 1EBM 1N3C 1YQK 1YQR 2I5W 2NOL |
Descriptor | N-glycosylase/DNA lyase, 5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*G)-3', 5'-D(AP*TP*CP*TP*GP*GP*AP*CP*CP*TP*GP*CP*A)-3' (3 entities in total) |
Functional Keywords | disulfide crosslink, dna glycosylase, undamaged dna, (hydrolase, lyase)-dna complex, dna damage, dna repair, glycosidase, hydrolase, lyase, mitochondrion, multifunctional enzyme, nucleus, lyase)/dna |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 43948.81 |
Authors | Verdine, G.L.,Crenshaw, C.M.,Oo, K.S.,Kutchukian, P.S. (deposition date: 2009-07-29, release date: 2010-11-03, Last modification date: 2023-09-06) |
Primary citation | Crenshaw, C.M.,Oo, K.S.,Kutchukian, P.S.,Verdine, G.L. A Catalytic Checkpoint in Base Excision by the Human 8-Oxoguanine DNA Glycosylase hOGG1 To be Published, |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
Download full validation report