3IG6

Low molecular weigth human Urokinase type Plasminogen activator 2-[6-(3'-Aminomethyl-biphenyl-3-yloxy)-4-(3-dimethylamino-pyrrolidin-1-yl)-3,5-difluoro-pyridin-2-yloxy]-4-dimethylamino-benzoic acid complex

Summary for 3IG6

• Entry DOI: 10.2210/pdb3ig6/pdb
• Related: 1f92 1owj 1sqa 1vja 1w14
• Descriptor: Urokinase-type plasminogen activator, 2-[(6-{[3'-(aminomethyl)biphenyl-3-yl]oxy}-4-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-3,5-difluoropyridin-2-yl)oxy]-4-(dimethylamino)benzoic acid, PHOSPHATE ION, ... (5 entities in total)
• Functional Keywords: selective, s1 site inhibitor, structure-based drug design, urokinase, blood coagulation, disulfide bond, egf-like domain, fibrinolysis, glycoprotein, hydrolase, kringle, pharmaceutical, phosphoprotein, plasminogen activation, polymorphism, protease, secreted, serine protease, zymogen
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 63639.48

Authors

Adler, M.,Whitlow, M. (deposition date: 2009-07-27, release date: 2009-10-13, Last modification date: 2024-10-30)

Primary citation

West, C.W.,Adler, M.,Arnaiz, D.,Chen, D.,Chu, K.,Gualtieri, G.,Ho, E.,Huwe, C.,Light, D.,Phillips, G.,Pulk, R.,Sukovich, D.,Whitlow, M.,Yuan, S.,Bryant, J.
Identification of orally bioavailable, non-amidine inhibitors of Urokinase Plasminogen Activator (uPA)
Bioorg.Med.Chem.Lett., 19:5712-5715, 2009

PubMed Abstract: In this Letter we report the synthesis and evaluation of a series of non-amidine inhibitors of Urokinase Plasminogen Activator (uPA). Starting from compound 1, a significant change provided compounds in which the amidine, binding in the S1 pocket, was replaced with a primary amine. Further modifications led to the identification of potent, selective, and orally bioavailable uPA inhibitors.

PubMed: 19703768
DOI: 10.1016/j.bmcl.2009.08.008

Experimental method

X-RAY DIFFRACTION (1.83 Å)