3IES

Firefly luciferase inhibitor complex

3IES の概要

• エントリーDOI: 10.2210/pdb3ies/pdb
• 関連するPDBエントリー: 3IEP 3IER
• 分子名称: Luciferin 4-monooxygenase, 5'-O-[(R)-[({3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]phenyl}carbonyl)oxy](hydroxy)phosphoryl]adenosine (3 entities in total)
• 機能のキーワード: oxidoreductase, monooxygenase, photoprotein, luminescence, atp-binding, magnesium, metal-binding, nucleotide-binding, peroxisome
• 由来する生物種: Photinus pyralis (North American firefly)
• 細胞内の位置: Peroxisome : P08659
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 61531.53

構造登録者

Lovell, S.,Battaile, K.P.,Auld, D.S.,Thorne, N.,Lea, W.A.,Maloney, D.J.,Shen, M.,Raj, G.,Thomas, C.J.,Simeonov, A.,Hanzlik, R.P.,Inglese, J. (登録日: 2009-07-23, 公開日: 2010-02-16, 最終更新日: 2023-09-06)

• 主引用文献: Auld, D.S.,Lovell, S.,Thorne, N.,Lea, W.A.,Maloney, D.J.,Shen, M.,Rai, G.,Battaile, K.P.,Thomas, C.J.,Simeonov, A.,Hanzlik, R.P.,Inglese, J.; Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124.; Proc.Natl.Acad.Sci.USA, 107:4878-4883, 2010; PubMed: 20194791; DOI: 10.1073/pnas.0909141107

実験手法

X-RAY DIFFRACTION (2 Å)