3IB1

Structural basis of the prevention of NSAID-induced damage of the gastrointestinal tract by C-terminal half (C-lobe) of bovine colostrum protein lactoferrin: Binding and structural studies of C-lobe complex with indomethacin

Replaces:  2ALTReplaces:  3HWZ

Summary for 3IB1

• Entry DOI: 10.2210/pdb3ib1/pdb
• Related: 2ALT
• Descriptor: Lactotransferrin, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-4)-alpha-D-mannopyranose-(1-4)-alpha-D-mannopyranose-(1-4)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• Functional Keywords: c-lobe, drugs, metal binding protein, antibiotic, antimicrobial, disulfide bond, glycoprotein, hydrolase, ion transport, iron, iron transport, metal-binding, phosphoprotein, protease, secreted, serine protease, transport
• Biological source: Bos taurus (Bovine)
• Total number of polymer chains: 1
• Total formula weight: 40236.74

Authors

Mir, R.,Singh, N.,Sinha, M.,Sharma, S.,Kaur, P.,Srinivasan, A.,Singh, T.P. (deposition date: 2009-07-15, release date: 2009-08-11, Last modification date: 2023-11-01)

• Primary citation: Mir, R.,Singh, N.,Vikram, G.,Kumar, R.P.,Sinha, M.,Bhushan, A.,Kaur, P.,Srinivasan, A.,Sharma, S.,Singh, T.P.; The structural basis for the prevention of nonsteroidal antiinflammatory drug-induced gastrointestinal tract damage by the C-lobe of bovine colostrum lactoferrin; Biophys.J., 97:3178-3186, 2009; PubMed: 20006955; DOI: 10.1016/j.bpj.2009.09.030

Experimental method

X-RAY DIFFRACTION (2.2 Å)