3IAW
Crystal structure of a chemically synthesized 203 amino acid 'covalent dimer' [Gly51;Aib51']HIV-1 protease molecule complexed with MVT-101 reduced isostere inhibitor at 1.6 A resolution
Summary for 3IAW
Entry DOI | 10.2210/pdb3iaw/pdb |
Related | 3FSM 3HAU 3HAW 3HBO 3HDK 3HLO |
Related PRD ID | PRD_000398 |
Descriptor | [Gly51;Aib51'] 'covalent dimer' HIV-1 protease, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide, SULFATE ION, ... (4 entities in total) |
Functional Keywords | asymmetric dimer, covalent dimer, beta-sheet, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Total number of polymer chains | 1 |
Total formula weight | 22786.75 |
Authors | Torbeev, V.Y.,Kent, S.B.H. (deposition date: 2009-07-14, release date: 2011-04-27, Last modification date: 2012-12-12) |
Primary citation | Torbeev, V.Y.,Raghuraman, H.,Hamelberg, D.,Tonelli, M.,Westler, W.M.,Perozo, E.,Kent, S.B. Protein conformational dynamics in the mechanism of HIV-1 protease catalysis. Proc.Natl.Acad.Sci.USA, 108:20982-20987, 2011 Cited by PubMed: 22158985DOI: 10.1073/pnas.1111202108 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.61 Å) |
Structure validation
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