3IAW

Crystal structure of a chemically synthesized 203 amino acid 'covalent dimer' [Gly51;Aib51']HIV-1 protease molecule complexed with MVT-101 reduced isostere inhibitor at 1.6 A resolution

3IAW の概要

• エントリーDOI: 10.2210/pdb3iaw/pdb
• 関連するPDBエントリー: 3FSM 3HAU 3HAW 3HBO 3HDK 3HLO
• 関連するBIRD辞書のPRD_ID: PRD_000398
• 分子名称: [Gly51;Aib51'] 'covalent dimer' HIV-1 protease, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: asymmetric dimer, covalent dimer, beta-sheet, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22786.75

構造登録者

Torbeev, V.Y.,Kent, S.B.H. (登録日: 2009-07-14, 公開日: 2011-04-27, 最終更新日: 2012-12-12)

• 主引用文献: Torbeev, V.Y.,Raghuraman, H.,Hamelberg, D.,Tonelli, M.,Westler, W.M.,Perozo, E.,Kent, S.B.; Protein conformational dynamics in the mechanism of HIV-1 protease catalysis.; Proc.Natl.Acad.Sci.USA, 108:20982-20987, 2011; PubMed: 22158985; DOI: 10.1073/pnas.1111202108

実験手法

X-RAY DIFFRACTION (1.61 Å)