3I6O
Crystal structure of wild type HIV-1 protease with macrocyclic inhibitor GRL-0216A
Summary for 3I6O
Entry DOI | 10.2210/pdb3i6o/pdb |
Related | 2HB3 2IEN 2Z4O 3DJK 3DK1 3H5B |
Descriptor | Protease, SODIUM ION, IODIDE ION, ... (6 entities in total) |
Functional Keywords | hiv-1, wild type protease, protease inhibitor, macrocyclic ligand, aids, aspartyl protease, hydrolase |
Biological source | Human immunodeficiency virus type 1 (BRU ISOLATE) (HIV-1) |
Cellular location | Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367 |
Total number of polymer chains | 2 |
Total formula weight | 24753.45 |
Authors | Chumanevich, A.A.,Wang, Y.-F.,Kovalevsky, A.Y.,Weber, I.T. (deposition date: 2009-07-07, release date: 2009-09-29, Last modification date: 2023-09-06) |
Primary citation | Ghosh, A.K.,Kulkarni, S.,Anderson, D.D.,Hong, L.,Baldridge, A.,Wang, Y.F.,Chumanevich, A.A.,Kovalevsky, A.Y.,Tojo, Y.,Amano, M.,Koh, Y.,Tang, J.,Weber, I.T.,Mitsuya, H. Design, Synthesis, Protein-Ligand X-ray Structure, and Biological Evaluation of a Series of Novel Macrocyclic Human Immunodeficiency Virus-1 Protease Inhibitors to Combat Drug Resistance. J.Med.Chem., 52:7689-7705, 2009 Cited by PubMed: 19746963DOI: 10.1021/jm900695w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.17 Å) |
Structure validation
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