Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 201 |
| Chain | Residue |
| A | ASP60 |
| A | HOH1023 |
| A | HOH1055 |
| A | HOH1076 |
| A | HOH1094 |
| A | HOH1107 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 211 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD A 216 |
| Chain | Residue |
| A | GLY48 |
| A | HOH1232 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD A 217 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 220 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD A 224 |
| Chain | Residue |
| A | GLN61 |
| A | IOD225 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 225 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD A 228 |
| Chain | Residue |
| A | LYS55 |
| A | HOH1195 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 303 |
| Chain | Residue |
| A | LYS14 |
| A | GLY16 |
| A | GLY17 |
| A | ILE63 |
| A | ILE64 |
| A | GLU65 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA B 202 |
| Chain | Residue |
| B | ASP160 |
| B | HOH1034 |
| B | HOH1048 |
| B | HOH1068 |
| B | HOH1069 |
| B | HOH1098 |
| site_id | BC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD B 212 |
| site_id | BC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD B 213 |
| site_id | BC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD B 214 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IOD B 215 |
| Chain | Residue |
| B | PRO144 |
| B | LYS155 |
| B | IOD214 |
| site_id | BC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD B 218 |
| site_id | BC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD B 219 |
| Chain | Residue |
| B | ILE163 |
| B | HOH1074 |
| site_id | BC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IOD B 221 |
| Chain | Residue |
| A | HOH1231 |
| B | GLY140 |
| B | HOH1236 |
| site_id | BC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD B 222 |
| site_id | CC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD B 223 |
| Chain | Residue |
| A | HOH1237 |
| B | GLU165 |
| site_id | CC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IOD B 226 |
| Chain | Residue |
| A | LYS55 |
| B | LYS170 |
| B | IOD227 |
| site_id | CC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD B 227 |
| Chain | Residue |
| A | LYS55 |
| B | IOD226 |
| site_id | CC4 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE GR6 B 301 |
| Chain | Residue |
| A | ARG8 |
| A | ASP25 |
| A | GLY27 |
| A | ALA28 |
| A | ASP29 |
| A | ASP30 |
| A | GLY48 |
| A | GLY49 |
| A | ILE50 |
| A | PRO81 |
| A | VAL82 |
| A | ILE84 |
| A | HOH1232 |
| B | ARG108 |
| B | ASP125 |
| B | GLY127 |
| B | ALA128 |
| B | ASP129 |
| B | ASP130 |
| B | GLY148 |
| B | GLY149 |
| B | ILE150 |
| B | PRO181 |
| B | VAL182 |
| B | ILE184 |
| B | HOH1001 |
| B | HOH1253 |
| site_id | CC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 302 |
| Chain | Residue |
| A | LEU5 |
| A | TRP6 |
| B | ASP129 |
| B | ARG187 |
| B | ASN188 |
| B | THR191 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVI |
| Chain | Residue | Details |
| A | ALA22-ILE33 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 138 |
| Details | Domain: {"description":"Peptidase A2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00275","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Region: {"description":"Dimerization of protease","evidences":[{"source":"UniProtKB","id":"P04585","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For protease activity; shared with dimeric partner","evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a30 |
| Chain | Residue | Details |
| A | ASP25 | |
| A | THR26 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a30 |
| Chain | Residue | Details |
| B | THR126 | |
| B | ASP125 | |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1a30 |
| Chain | Residue | Details |
| A | ASP25 | |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1a30 |
| Chain | Residue | Details |
| B | ASP125 | |
