3I4A

Crystal structure of dimethylarginine dimethylaminohydrolase-1 (DDAH-1) in complex with N5-(1-iminopropyl)-L-ornithine

3I4A の概要

• エントリーDOI: 10.2210/pdb3i4a/pdb
• 関連するPDBエントリー: 2JAI 2JAJ 3I2E
• 分子名称: N(G),N(G)-dimethylarginine dimethylaminohydrolase 1, N5-(1-iminopropyl)-L-ornithine (3 entities in total)
• 機能のキーワード: ddah, hydrolase, nitric oxide synthase regulation, metal-binding
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 67621.46

構造登録者

Monzingo, A.F.,Wang, Y.,Hu, S.,Schaller, T.H.,Fast, W.,Robertus, J.D. (登録日: 2009-07-01, 公開日: 2009-08-25, 最終更新日: 2023-09-06)

• 主引用文献: Wang, Y.,Monzingo, A.F.,Hu, S.,Schaller, T.H.,Robertus, J.D.,Fast, W.; Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide.; Biochemistry, 48:8624-8635, 2009; PubMed: 19663506; DOI: 10.1021/bi9007098

実験手法

X-RAY DIFFRACTION (1.898 Å)