3I2L
Crystal structure of a chemically synthesized [allo-Ile50/50']HIV-1 protease molecule complexed with MVT-101 reduced isostere inhibitor
Summary for 3I2L
Entry DOI | 10.2210/pdb3i2l/pdb |
Related | 3FSM 3HAU 3HAW 3HBO 3HDK 3HLO |
Related PRD ID | PRD_000398 |
Descriptor | HIV-1 protease, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide (3 entities in total) |
Functional Keywords | beta-sheet, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Total number of polymer chains | 2 |
Total formula weight | 22292.23 |
Authors | Torbeev, V.Y.,Kent, S.B.H. (deposition date: 2009-06-29, release date: 2011-04-27, Last modification date: 2014-02-12) |
Primary citation | Torbeev, V.Y.,Kent, S.B.H. Hydrogen bonds at the protein-inhibitor interface in the HIV-1 protease / inhibitors complexes probed by total chemical synthesis and X-ray crystallography To be Published, |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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