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3I2L

Crystal structure of a chemically synthesized [allo-Ile50/50']HIV-1 protease molecule complexed with MVT-101 reduced isostere inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0004190molecular_functionaspartic-type endopeptidase activity
A0006508biological_processproteolysis
B0004190molecular_functionaspartic-type endopeptidase activity
B0006508biological_processproteolysis
Functional Information from PDB Data
site_idAC1
Number of Residues25
DetailsBINDING SITE FOR RESIDUE 2NC B 100
ChainResidue
AASP25
APHE53
APRO81
AVAL82
AILE84
AHOH101
BASP25
BGLY27
BALA28
BASP29
BASP30
AGLY27
BILE47
BGLY48
BGLY49
BIIL50
BPRO81
BILE84
AALA28
AASP29
AASP30
AILE47
AGLY48
AGLY49
AIIL50

Functional Information from PROSITE/UniProt
site_idPS00141
Number of Residues12
DetailsASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVI
ChainResidueDetails
AALA22-ILE33

222926

PDB entries from 2024-07-24

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