3HYF

Crystal structure of HIV-1 RNase H p15 with engineered E. coli loop and active site inhibitor

3HYF の概要

• エントリーDOI: 10.2210/pdb3hyf/pdb
• 分子名称: Reverse transcriptase/RNaseH, MANGANESE (II) ION, ACETATE ION, ... (6 entities in total)
• 機能のキーワード: rnase h, hiv-1, hydrolase, di-valent metal nucleic acid cleavage mechanism, di-valent metal coordination, aspartyl protease, dna integration, dna recombination, endonuclease, multifunctional enzyme, nuclease, nucleotidyltransferase, protease, rna-directed dna polymerase, transferase, magnesium, metal-binding
• 由来する生物種: Human immunodeficiency virus 1; 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17589.68

構造登録者

Lansdon, E.B.,Kirschberg, T.A. (登録日: 2009-06-22, 公開日: 2009-10-20, 最終更新日: 2024-03-13)

• 主引用文献: Kirschberg, T.A.,Balakrishnan, M.,Squires, N.H.,Barnes, T.,Brendza, K.M.,Chen, X.,Eisenberg, E.J.,Jin, W.,Kutty, N.,Leavitt, S.,Liclican, A.,Liu, Q.,Liu, X.,Mak, J.,Perry, J.K.,Wang, M.,Watkins, W.J.,Lansdon, E.B.; RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: design, biochemical activity, and structural information.; J.Med.Chem., 52:5781-5784, 2009; PubMed: 19791799; DOI: 10.1021/jm900597q

実験手法

X-RAY DIFFRACTION (1.7 Å)