3HVO

Structure of the genotype 2B HCV polymerase bound to a NNI

3HVO の概要

• エントリーDOI: 10.2210/pdb3hvo/pdb
• 関連するPDBエントリー: 2WHO 3GSZ
• 分子名称: Genome polyprotein, 2-(3-bromophenyl)-6-[(2-hydroxyethyl)amino]-1h-benzo[de]isoquinoline-1,3(2h)-dione (3 entities in total)
• 機能のキーワード: viral polymerase, atp-binding, hydrolase, metal-binding, multifunctional enzyme, nucleotide-binding, nucleotidyltransferase, rna replication, rna-binding, rna-directed rna polymerase, transferase
• 由来する生物種: Hepatitis C virus isolate HC-J8 (HCV)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 126362.13

構造登録者

Rydberg, E.H.,Carfi, A. (登録日: 2009-06-16, 公開日: 2009-08-04, 最終更新日: 2023-11-01)

• 主引用文献: Ontoria, J.M.,Rydberg, E.H.,Di-Marco, S.,Tomei, L.,Antenni, B.,Melancona, S.,Martin-Hernando, J.I.,Gennari, N.,Koch, U.,Narjes, F.,Rowley, M.,Summa, V.,Carroll, S.S.,Olsen, D.B.,De-Francesco, R.,Altamura, S.,Migliaccio, G.,Carfi, A.; Identification and Biological Evaluation of a Series of 1H-Benzo[de]isoquinoline-1,3(2H)-diones as Hepatitis C Virus NS5B Polymerase Inhibitors; To be Published,

実験手法

X-RAY DIFFRACTION (2 Å)