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3HVO

Structure of the genotype 2B HCV polymerase bound to a NNI

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0003968molecular_functionRNA-dependent RNA polymerase activity
A0039694biological_processviral RNA genome replication
B0003723molecular_functionRNA binding
B0003968molecular_functionRNA-dependent RNA polymerase activity
B0039694biological_processviral RNA genome replication
Functional Information from PDB Data
site_idAC1
Number of Residues9
DetailsBINDING SITE FOR RESIDUE VGI A 564
ChainResidue
AASN329
AILE419
AARG422
AMET423
AALA435
ALEU474
ATRP528
AHOH694
AHOH1001

site_idAC2
Number of Residues13
DetailsBINDING SITE FOR RESIDUE VGI B 564
ChainResidue
BASN329
BILE419
BARG422
BMET423
BGLN436
BLEU474
BARG498
BTRP528
BHOH629
BHOH681
BHOH827
BHOH1010
BHOH1016

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P26663
ChainResidueDetails
AASP220
AASP318
AASP319
BASP220
BASP318
BASP319

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphoserine; by host => ECO:0000250|UniProtKB:P26662
ChainResidueDetails
ASER29
ASER42
BSER29
BSER42

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PDB entries from 2024-11-06

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