3HVO
Structure of the genotype 2B HCV polymerase bound to a NNI
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Genome polyprotein | polymer | 563 | 62769.8 | 2 | UniProt (P26661) | Hepatitis C virus isolate HC-J8 (HCV) | RNA-directed RNA polymerase, NS5B, P68 |
| 2 | C, D (A, B) | 2-(3-bromophenyl)-6-[(2-hydroxyethyl)amino]-1h-benzo[de]isoquinoline-1,3(2h)-dione | non-polymer | 411.2 | 2 | Chemie (VGI) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 851 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 563 (UniProt: P26661)
| PDB | External Database | Details |
|---|---|---|
| Thr 5 | Ser 2447 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 125539.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 822.5 | |
| All* | Total formula weight | 126362.1 |
