3GSZ

Structure of the genotype 2B HCV polymerase

Summary for 3GSZ

• Entry DOI: 10.2210/pdb3gsz/pdb
• Descriptor: RNA-directed RNA polymerase (2 entities in total)
• Functional Keywords: polymerase, hcv, transferase
• Biological source: Hepatitis C virus isolate HC-J8 (HCV)
• Cellular location: Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P26661
• Total number of polymer chains: 2
• Total formula weight: 125539.63

Authors

Rydberg, E.H.,Carfi, A. (deposition date: 2009-03-27, release date: 2009-07-07, Last modification date: 2024-02-21)

• Primary citation: Rydberg, E.H.,Cellucci, A.,Bartholomew, L.,Mattu, M.,Barbato, G.,Ludmerer, S.W.,Graham, D.J.,Altamura, S.,Paonessa, G.,De Francesco, R.,Migliaccio, G.,Carfi, A.; Structural basis for resistance of the genotype 2b hepatitis C virus NS5B polymerase to site A non-nucleoside inhibitors.; J.Mol.Biol., 390:1048-1059, 2009; PubMed: 19505479; DOI: 10.1016/j.jmb.2009.06.012

Experimental method

X-RAY DIFFRACTION (1.9 Å)