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3HVL

Tethered PXR-LBD/SRC-1p complexed with SR-12813

Replaces:  3CTC
Summary for 3HVL
Entry DOI10.2210/pdb3hvl/pdb
Related1ILG 1ILH 1NRL 3CTB
DescriptorPregnane X receptor, Linker, Steroid receptor coactivator 1, [2-(3,5-DI-TERT-BUTYL-4-HYDROXY-PHENYL)-1-(DIETHOXY-PHOSPHORYL)-VINYL]-PHOSPHONIC ACID DIETHLYL ESTER (3 entities in total)
Functional Keywordspxr, src-1, tethered, engineered, drug-drug interactions, dna-binding, metal-binding, nucleus, receptor, transcription, transcription regulation, zinc-finger, transferase
Biological sourceHomo sapiens (human)
More
Cellular locationNucleus : Q15788
Total number of polymer chains2
Total formula weight79377.14
Authors
Lesburg, C.A.,Wang, W.,Prosise, W.W.,Chen, J.,Taremi, S.S.,Le, H.V.,Madison, V.,Cui, X.,Thomas, A.,Cheng, K.C. (deposition date: 2009-06-16, release date: 2009-08-04, Last modification date: 2024-02-21)
Primary citationWang, W.,Prosise, W.W.,Chen, J.,Taremi, S.S.,Le, H.V.,Madison, V.,Cui, X.,Thomas, A.,Cheng, K.C.,Lesburg, C.A.
Construction and characterization of a fully active PXR/SRC-1 tethered protein with increased stability
Protein Eng.Des.Sel., 21:425-433, 2008
Cited by
PubMed: 18456871
DOI: 10.1093/protein/gzn017
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

217705

数据于2024-03-27公开中

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