3HVL

Tethered PXR-LBD/SRC-1p complexed with SR-12813

Replaces:  3CTC

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Pregnane X receptor, Linker, Steroid receptor coactivator 1	polymer	344	39184.0	2	UniProt (O75469) UniProt (Q15788) Pfam (PF00104) In PDB	Homo sapiens (human)	Nuclear receptor subfamily 1 group I member 2, Orphan nuclear receptor PXR, Orphan nuclear receptor PAR1, Steroid and xenobiotic receptor, SXR, NCoA-1, SRC-1, RIP160, Protein Hin-2, Renal carcinoma antigen NY-REN-52, Nuclear receptor coactivator 1
2	A, B	[2-(3,5-DI-TERT-BUTYL-4-HYDROXY-PHENYL)-1-(DIETHOXY-PHOSPHORYL)-VINYL]-PHOSPHONIC ACID DIETHLYL ESTER	non-polymer		504.5	2	Chemie (SRL)
3		water	water		18.0	257	Chemie (HOH)

Sequence modifications

A, B: 130 - 434 (UniProt: O75469)

PDB	External Database	Details
Met 119	-	expression tag
Lys 120	-	expression tag
Lys 121	-	expression tag
Gly 122	-	expression tag
His 123	-	expression tag
His 124	-	expression tag
His 125	-	expression tag
His 126	-	expression tag
His 127	-	expression tag
His 128	-	expression tag
Gly 129	-	expression tag
Gly 435	-	linker
Gly 436	-	linker
Ser 437	-	linker
Gly 438	-	linker
Gly 439	-	linker

A, B: 440 - 462 (UniProt: Q15788)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	78368.1
Non-Polymers*	Number of molecules	2
	Total formula weight	1009.1
All*	Total formula weight	79377.1

*Water molecules are not included.