3HVL

Tethered PXR-LBD/SRC-1p complexed with SR-12813

3CTC」から置き換えられました

3HVL の概要

関連するPDBエントリー1NRL 1ILH 1ILG 3CTB
分子名称Pregnane X receptor, Linker, Steroid receptor coactivator 1, [2-(3,5-DI-TERT-BUTYL-4-HYDROXY-PHENYL)-1-(DIETHOXY-PHOSPHORYL)-VINYL]-PHOSPHONIC ACID DIETHLYL ESTER (3 entities in total)
機能のキーワードpxr, src-1, tethered, engineered, drug-drug interactions, dna-binding, metal-binding, nucleus, receptor, transcription, transcription regulation, zinc-finger, transferase
由来する生物種Homo sapiens (human)
細胞内の位置Nucleus  Q15788
ポリマー鎖数2
分子量合計79377.14
構造登録者
Lesburg, C.A.,Wang, W.,Prosise, W.W.,Chen, J.,Taremi, S.S.,Le, H.V.,Madison, V.,Cui, X.,Thomas, A.,Cheng, K.C. (登録日: 2009-06-16, 公開日: 2009-08-04, 最終更新日: 2017-08-16)
主引用文献
Wang, W.,Prosise, W.W.,Chen, J.,Taremi, S.S.,Le, H.V.,Madison, V.,Cui, X.,Thomas, A.,Cheng, K.C.,Lesburg, C.A.
Construction and characterization of a fully active PXR/SRC-1 tethered protein with increased stability
Protein Eng.Des.Sel., 21:425-433, 2008
PubMed: 18456871 (主引用文献が同じPDBエントリー)
DOI: 10.1093/protein/gzn017
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.1 Å)
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構造検証レポート

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers211.4%9.6%6.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード