3HOB
Factor VIII Trp2313-His2315 segment is involved in membrane binding as shown by crystal structure of complex between factor VIII C2 domain and an inhibitor
Summary for 3HOB
Entry DOI | 10.2210/pdb3hob/pdb |
Related | 3HNY |
Descriptor | Coagulation factor VIII (2 entities in total) |
Functional Keywords | blood clotting, acute phase, blood coagulation, calcium, disease mutation, disulfide bond, glycoprotein, hemophilia, metal-binding, pharmaceutical, polymorphism, secreted, sulfation |
Biological source | Homo sapiens (human) |
Cellular location | Secreted, extracellular space: P00451 |
Total number of polymer chains | 2 |
Total formula weight | 36059.12 |
Authors | |
Primary citation | Liu, Z.,Lin, L.,Yuan, C.,Nicolaes, G.A.,Chen, L.,Meehan, E.J.,Furie, B.,Furie, B.,Huang, M. Trp2313-His2315 of factor VIII C2 domain is involved in membrane binding: structure of a complex between the C2 domain and an inhibitor of membrane binding. J.Biol.Chem., 285:8824-8829, 2010 Cited by PubMed: 20089867DOI: 10.1074/jbc.M109.080168 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.07 Å) |
Structure validation
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