3HNY

Factor VIII Trp2313-His2315 segment is involved in membrane binding as shown by crystal structure of complex between factor VIII C2 domain and an inhibitor

Summary for 3HNY

Entry DOI	10.2210/pdb3hny/pdb
Descriptor	Coagulation factor VIII (2 entities in total)
Functional Keywords	blood clotting, acute phase, blood coagulation, calcium, disease mutation, disulfide bond, glycoprotein, hemophilia, metal-binding, pharmaceutical, polymorphism, secreted, sulfation
Biological source	Homo sapiens (human)
Cellular location	Secreted, extracellular space: P00451
Total number of polymer chains	1
Total formula weight	18029.56
Authors	Liu, Z.,Yuan, C. (deposition date: 2009-06-01, release date: 2010-01-19, Last modification date: 2023-11-01)
Primary citation	Liu, Z.,Lin, L.,Yuan, C.,Nicolaes, G.A.,Chen, L.,Meehan, E.J.,Furie, B.,Furie, B.,Huang, M. Trp2313-His2315 of factor VIII C2 domain is involved in membrane binding: structure of a complex between the C2 domain and an inhibitor of membrane binding. J.Biol.Chem., 285:8824-8829, 2010 Cited by PubMed: 20089867 DOI: 10.1074/jbc.M109.080168 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.07 Å)

Structure validation