3HOB

Factor VIII Trp2313-His2315 segment is involved in membrane binding as shown by crystal structure of complex between factor VIII C2 domain and an inhibitor

3HOB の概要

• エントリーDOI: 10.2210/pdb3hob/pdb
• 関連するPDBエントリー: 3HNY
• 分子名称: Coagulation factor VIII (2 entities in total)
• 機能のキーワード: blood clotting, acute phase, blood coagulation, calcium, disease mutation, disulfide bond, glycoprotein, hemophilia, metal-binding, pharmaceutical, polymorphism, secreted, sulfation
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted, extracellular space: P00451
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 36059.12

構造登録者

Liu, Z.,Yuan, C. (登録日: 2009-06-01, 公開日: 2010-01-19, 最終更新日: 2023-11-01)

• 主引用文献: Liu, Z.,Lin, L.,Yuan, C.,Nicolaes, G.A.,Chen, L.,Meehan, E.J.,Furie, B.,Furie, B.,Huang, M.; Trp2313-His2315 of factor VIII C2 domain is involved in membrane binding: structure of a complex between the C2 domain and an inhibitor of membrane binding.; J.Biol.Chem., 285:8824-8829, 2010; PubMed: 20089867; DOI: 10.1074/jbc.M109.080168

実験手法

X-RAY DIFFRACTION (2.07 Å)