3HNB
Factor VIII Trp2313-His2315 segment is involved in membrane binding as shown by crystal structure of complex between factor VIII C2 domain and an inhibitor
Summary for 3HNB
Entry DOI | 10.2210/pdb3hnb/pdb |
Descriptor | Coagulation factor VIII, (2R)-1-(2,4-dichlorophenoxy)-3-[(2E)-2-imino-3-(2-piperidin-1-ylethyl)-2,3-dihydro-1H-benzimidazol-1-yl]propan-2-ol (3 entities in total) |
Functional Keywords | small molecule inhibitor/blood clotting, blood clotting |
Biological source | Homo sapiens (human) |
Cellular location | Secreted, extracellular space: P00451 |
Total number of polymer chains | 1 |
Total formula weight | 18492.96 |
Authors | |
Primary citation | Liu, Z.,Lin, L.,Yuan, C.,Nicolaes, G.A.,Chen, L.,Meehan, E.J.,Furie, B.,Furie, B.,Huang, M. Trp2313-His2315 of factor VIII C2 domain is involved in membrane binding: structure of a complex between the C2 domain and an inhibitor of membrane binding. J.Biol.Chem., 285:8824-8829, 2010 Cited by PubMed: 20089867DOI: 10.1074/jbc.M109.080168 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.15 Å) |
Structure validation
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