3HNB
Factor VIII Trp2313-His2315 segment is involved in membrane binding as shown by crystal structure of complex between factor VIII C2 domain and an inhibitor
3HNB の概要
エントリーDOI | 10.2210/pdb3hnb/pdb |
分子名称 | Coagulation factor VIII, (2R)-1-(2,4-dichlorophenoxy)-3-[(2E)-2-imino-3-(2-piperidin-1-ylethyl)-2,3-dihydro-1H-benzimidazol-1-yl]propan-2-ol (3 entities in total) |
機能のキーワード | small molecule inhibitor/blood clotting, blood clotting |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Secreted, extracellular space: P00451 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 18492.96 |
構造登録者 | |
主引用文献 | Liu, Z.,Lin, L.,Yuan, C.,Nicolaes, G.A.,Chen, L.,Meehan, E.J.,Furie, B.,Furie, B.,Huang, M. Trp2313-His2315 of factor VIII C2 domain is involved in membrane binding: structure of a complex between the C2 domain and an inhibitor of membrane binding. J.Biol.Chem., 285:8824-8829, 2010 Cited by PubMed: 20089867DOI: 10.1074/jbc.M109.080168 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.15 Å) |
構造検証レポート
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