3HMW

Crystal structure of ustekinumab FAB

Summary for 3HMW

• Entry DOI: 10.2210/pdb3hmw/pdb
• Descriptor: USTEKINUMAB FAB LIGHT CHAIN, USTEKINUMAB FAB HEAVY CHAIN, CADMIUM ION, ... (4 entities in total)
• Functional Keywords: ustekinumab, cnto1275, il-12, il-23, antibody, fab, monoclonal antibody, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 48061.27

Authors

Luo, J. (deposition date: 2009-05-29, release date: 2010-06-09, Last modification date: 2015-07-22)

• Primary citation: Luo, J.,Wu, S.J.,Lacy, E.R.,Orlovsky, Y.,Baker, A.,Teplyakov, A.,Obmolova, G.,Heavner, G.A.,Richter, H.T.,Benson, J.; Structural basis for the dual recognition of IL-12 and IL-23 by ustekinumab.; J.Mol.Biol., 402:797-812, 2010; PubMed: 20691190; DOI: 10.1016/j.jmb.2010.07.046

Experimental method

X-RAY DIFFRACTION (3 Å)