3HMV

Catalytic domain of human phosphodiesterase 4B2B in complex with a tetrahydrobenzothiophene inhibitor

Summary for 3HMV

• Entry DOI: 10.2210/pdb3hmv/pdb
• Descriptor: cAMP-specific 3',5'-cyclic phosphodiesterase 4B, ZINC ION, MAGNESIUM ION, ... (6 entities in total)
• Functional Keywords: pde, phosphodiesterase, camp, alternative splicing, hydrolase, phosphoprotein, polymorphism
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 87862.03

Authors

Somers, D.O.,Neu, M. (deposition date: 2009-05-29, release date: 2010-06-09, Last modification date: 2024-04-03)

• Primary citation: Kranz, M.,Wall, M.,Evans, B.,Miah, A.,Ballantine, S.,Delves, C.,Dombroski, B.,Gross, J.,Schneck, J.,Villa, J.P.,Neu, M.,Somers, D.O.; Identification of PDE4B Over 4D subtype-selective inhibitors revealing an unprecedented binding mode; Bioorg.Med.Chem., 17:5336-5341, 2009; PubMed: 19525117; DOI: 10.1016/j.bmc.2009.03.061

Experimental method

X-RAY DIFFRACTION (2.23 Å)