3HMV
Catalytic domain of human phosphodiesterase 4B2B in complex with a tetrahydrobenzothiophene inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | polymer | 378 | 43435.9 | 2 | UniProt (Q07343) Pfam (PF00233) In PDB | Homo sapiens (human) | DPDE4, PDE32 |
| 2 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | A, B | (6S)-6-methyl-2-{[(2-nitrophenyl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide | non-polymer | 359.4 | 2 | Chemie (HBT) | |||
| 5 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | water | water | 18.0 | 255 | Chemie (HOH) |
Sequence modifications
A, B: 152 - 528 (UniProt: Q07343)
| PDB | External Database | Details |
|---|---|---|
| Met 151 | - | expression tag |
| Ala 482 | Ser 654 | engineered mutation |
| Ala 487 | Ser 659 | engineered mutation |
| Ala 489 | Ser 661 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 86871.7 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 990.3 | |
| All* | Total formula weight | 87862.0 |
