3HM1

Crystal structure of human Estrogen Receptor Alpha Ligand-Binding Domain in complex with a Glucocorticoid Receptor Interacting Protein 1 Nr Box II Peptide and estrone ((8R,9S,13S,14S)-3-hydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one)

Summary for 3HM1

• Entry DOI: 10.2210/pdb3hm1/pdb
• Descriptor: Estrogen receptor, Nuclear receptor coactivator 2, (9beta,13alpha)-3-hydroxyestra-1,3,5(10)-trien-17-one, ... (4 entities in total)
• Functional Keywords: estrogen receptor, lbd, grip peptide, estrone, alternative splicing, dna-binding, glycoprotein, lipid-binding, metal-binding, nucleus, phosphoprotein, polymorphism, receptor, steroid-binding, transcription, transcription regulation, zinc, zinc-finger, activator, hormone, nuclear receptor
• Biological source: Homo sapiens (human)
• Cellular location: Isoform 1: Nucleus. Isoform 3: Nucleus: P03372; Nucleus: Q9WUI9
• Total number of polymer chains: 4
• Total formula weight: 62043.49

Authors

Rajan, S.S.,Kim, Y.,Vanek, K.,Liwanag, M.,Joachimiak, A.,Greene, G.L. (deposition date: 2009-05-28, release date: 2010-06-02, Last modification date: 2023-09-06)

• Primary citation: Rajan, S.S.,Kim, Y.,Vanek, K.,Joachimiak, A.,Greene, G.L.; Crystal structure of human Estrogen Receptor Alpha Ligand-Binding Domain in complex with a Glucocorticoid Receptor Interacting Protein 1 Nr Box II Peptide and estrone ((8R,9S,13S,14S)-3-hydroxy-13-methyl-7,8,9,11,12,14,15, 16-octahydro-6H-cyclopenta[a]phenanthren-17-one); To be Published,

Experimental method

X-RAY DIFFRACTION (2.33 Å)