3HM1
Crystal structure of human Estrogen Receptor Alpha Ligand-Binding Domain in complex with a Glucocorticoid Receptor Interacting Protein 1 Nr Box II Peptide and estrone ((8R,9S,13S,14S)-3-hydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Estrogen receptor | polymer | 253 | 29171.5 | 2 | UniProt (P03372) Pfam (PF00104) In PDB | Homo sapiens (human) | ER, Estradiol receptor, ER-alpha, Nuclear receptor subfamily 3 group A member 1 |
| 2 | C, D | Nuclear receptor coactivator 2 | polymer | 13 | 1579.9 | 2 | UniProt (Q9WUI9) In PDB | NCoA-2, Transcriptional intermediary factor 2 | |
| 3 | A, B | (9beta,13alpha)-3-hydroxyestra-1,3,5(10)-trien-17-one | non-polymer | 270.4 | 2 | Chemie (J3Z) | |||
| 4 | water | water | 18.0 | 10 | Chemie (HOH) |
Sequence modifications
A, B: 298 - 550 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Ser 537 | Tyr 537 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 61502.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 540.7 | |
| All* | Total formula weight | 62043.5 |
