3HM1
Crystal structure of human Estrogen Receptor Alpha Ligand-Binding Domain in complex with a Glucocorticoid Receptor Interacting Protein 1 Nr Box II Peptide and estrone ((8R,9S,13S,14S)-3-hydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Estrogen receptor | polymer | 253 | 29171.5 | 2 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (human) | ER, Estradiol receptor, ER-alpha, Nuclear receptor subfamily 3 group A member 1 |
| 2 | C, D (C, D) | Nuclear receptor coactivator 2 | polymer | 13 | 1579.9 | 2 | UniProt (Q9WUI9) | NCoA-2, Transcriptional intermediary factor 2 | |
| 3 | E, F (A, B) | (9beta,13alpha)-3-hydroxyestra-1,3,5(10)-trien-17-one | non-polymer | 270.4 | 2 | Chemie (J3Z) PubChem (698) PubChem (5870) PubChem (133184) PubChem (657358) PubChem (667482) PubChem (5702052) PubChem (6336180) PubChem (6540830) PubChem (6603847) PubChem (6710658) PubChem (6918970) PubChem (6954895) PubChem (7059424) PubChem (9547221) PubChem (10989336) PubChem (11869378) PubChem (11869537) PubChem (12305076) PubChem (46781514) PubChem (670995) PubChem (928336) PubChem (56619853) PubChem (7059423) PubChem (68209946) PubChem (71774672) PubChem (133638141) PubChem (141767110) PubChem (143400863) PubChem (145187136) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 10 | Chemie (HOH) |
Sequence modifications
A, B: 298 - 550 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Ser 537 | Tyr 537 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 61502.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 540.7 | |
| All* | Total formula weight | 62043.5 |
