3HKJ

Crystal structure of human thrombin mutant W215A/E217A in complex with the extracellular fragment of human PAR1

3HKJ の概要

• エントリーDOI: 10.2210/pdb3hkj/pdb
• 関連するPDBエントリー: 1TQ0 3HK3 3HK6 3HKI
• 分子名称: Thrombin light chain, Thrombin heavy chain, Proteinase-activated receptor 1, ... (5 entities in total)
• 機能のキーワード: serine protease, acute phase, blood coagulation, cleavage on pair of basic residues, disease mutation, disulfide bond, gamma-carboxyglutamic acid, glycoprotein, hydrolase, kringle, protease, secreted, zymogen, cell membrane, g-protein coupled receptor, membrane, phosphoprotein, receptor, transducer, transmembrane
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 72298.40

構造登録者

Gandhi, P.S.,Page, M.J.,Chen, Z.,Bush-Pelc, L.,Di Cera, E. (登録日: 2009-05-23, 公開日: 2009-07-07, 最終更新日: 2023-09-06)

• 主引用文献: Gandhi, P.S.,Page, M.J.,Chen, Z.,Bush-Pelc, L.,Di Cera, E.; Mechanism of the Anticoagulant Activity of Thrombin Mutant W215A/E217A.; J.Biol.Chem., 284:24098-24105, 2009; PubMed: 19586901; DOI: 10.1074/jbc.M109.025403

実験手法

X-RAY DIFFRACTION (2.6 Å)