3HKJ
Crystal structure of human thrombin mutant W215A/E217A in complex with the extracellular fragment of human PAR1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | Thrombin light chain | polymer | 31 | 3647.1 | 2 | UniProt (P00734) Pfam (PF09396) | Homo sapiens (human) | Coagulation factor II |
| 2 | B, E (B, E) | Thrombin heavy chain | polymer | 259 | 29607.1 | 2 | UniProt (P00734) Pfam (PF00089) | Homo sapiens (human) | Coagulation factor II |
| 3 | C, F (C, F) | Proteinase-activated receptor 1 | polymer | 21 | 2673.9 | 2 | UniProt (P25116) | Homo sapiens (human) | PAR-1, Thrombin receptor, Coagulation factor II receptor |
| 4 | G, H (B, E) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 5 | I, J, K, L, M... (A, B, C, D, E...) | water | water | 18.0 | 154 | Chemie (HOH) |
Sequence modifications
B, E: 16 - 247 (UniProt: P00734)
| PDB | External Database | Details |
|---|---|---|
| Ala 215 | Trp 590 | engineered mutation |
| Ala 217 | Glu 592 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 71856.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 442.4 | |
| All* | Total formula weight | 72298.4 |
