3HJ3

Crystal Structure of the ChTS-DHFR F207A Non-Active Site Mutant

Summary for 3HJ3

Entry DOI	10.2210/pdb3hj3/pdb
Descriptor	Chain A, crystal structure of Dhfr, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, ... (6 entities in total)
Functional Keywords	ts, dhfr, enzyme, crossover, non-active site, oxidoreductase
Biological source	Cryptosporidium hominis
Total number of polymer chains	4
Total formula weight	247902.10
Authors	Anderson, K.S.,Martucci, W.E. (deposition date: 2009-05-20, release date: 2010-06-02, Last modification date: 2023-09-06)
Primary citation	Martucci, W.E.,Rodriguez, J.M.,Vargo, M.A.,Marr, M.,Hamilton, A.D.,Anderson, K.S. Exploring novel strategies for AIDS protozoal pathogens: alpha-helix mimetics targeting a key allosteric protein-protein interaction in C. hominis TS-DHFR. Medchemcomm, 4:1247-1256, 2013 Cited by PubMed: 24324854 DOI: 10.1039/C3MD00141E PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation