3HJ3
Crystal Structure of the ChTS-DHFR F207A Non-Active Site Mutant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Chain A, crystal structure of Dhfr | polymer | 521 | 60186.4 | 4 | UniProt (Q5CGA3) | Cryptosporidium hominis | |
| 2 | E, I, M (A, B, C) | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE | non-polymer | 308.2 | 3 | Chemie (UMP) | |||
| 3 | F, J, N (A, B, C) | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID | non-polymer | 477.5 | 3 | Chemie (CB3) | |||
| 4 | G, K, O, Q (A, B, C, D) | METHOTREXATE | non-polymer | 454.4 | 4 | Chemie (MTX) | |||
| 5 | H, L, P, R (A, B, C, D) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 4 | Chemie (NDP) | |||
| 6 | S, T, U, V (A, B, C, D) | water | water | 18.0 | 267 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 521 (UniProt: Q5CGA3)
| PDB | External Database | Details |
|---|---|---|
| Ala 207 | Phe 207 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 240745.7 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 7156.4 | |
| All* | Total formula weight | 247902.1 |
