3HIT

Crystal structure of Saporin-L1 in complex with the dinucleotide inhibitor, a transition state analogue

3HIT の概要

• エントリーDOI: 10.2210/pdb3hit/pdb
• 関連するPDBエントリー: 3HIO 3HIQ 3HIS 3HIV 3HIW
• 分子名称: Vacuolar saporin, 5'-O-[(S)-{[(3R,4R)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-({[(S)-hydroxy(3-hydroxypropoxy)phosphoryl]oxy}methyl)pyrrolidin-3-yl]oxy}(hydroxy)phosphoryl]-3'-O-[(R)-hydroxy(4-hydroxybutoxy)phosphoryl]-2'-O-methylguanosine (3 entities in total)
• 機能のキーワード: transition state, ribosome inactivating proteins, rips, hydrolase, plant defense, protein synthesis inhibitor, toxin, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Saponaria officinalis (Common soapwort)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 59360.89

構造登録者

Ho, M.,Sturm, M.B.,Almo, S.C.,Schramm, V.L. (登録日: 2009-05-20, 公開日: 2009-12-08, 最終更新日: 2024-02-21)

• 主引用文献: Ho, M.C.,Sturm, M.B.,Almo, S.C.,Schramm, V.L.; Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins.; Proc.Natl.Acad.Sci.USA, 106:20276-20281, 2009; PubMed: 19920175; DOI: 10.1073/pnas.0911606106

実験手法

X-RAY DIFFRACTION (2.29 Å)