3HHI

Crystal Structure of Cathepsin B from T. brucei in complex with CA074

3HHI の概要

• エントリーDOI: 10.2210/pdb3hhi/pdb
• 関連するBIRD辞書のPRD_ID: PRD_001032
• 分子名称: Cathepsin B-like cysteine protease, [PROPYLAMINO-3-HYDROXY-BUTAN-1,4-DIONYL]-ISOLEUCYL-PROLINE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (7 entities in total)
• 機能のキーワード: cysteine protease, occluding loop, hydrolase, protease, thiol protease
• 由来する生物種: Trypanosoma brucei
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 73318.60

構造登録者

Wu, P.,Kerr, I.D.,Brinen, L.S. (登録日: 2009-05-15, 公開日: 2010-05-26, 最終更新日: 2023-09-06)

主引用文献

Kerr, I.D.,Wu, P.,Marion-Tsukamaki, R.,Mackey, Z.B.,Brinen, L.S.
Crystal Structures of TbCatB and rhodesain, potential chemotherapeutic targets and major cysteine proteases of Trypanosoma brucei
Plos Negl Trop Dis, 4:e701-e701, 2010

PubMed Abstract: Trypanosoma brucei is the etiological agent of Human African Trypanosomiasis, an endemic parasitic disease of sub-Saharan Africa. TbCatB and rhodesain are the sole Clan CA papain-like cysteine proteases produced by the parasite during infection of the mammalian host and are implicated in the progression of disease. Of considerable interest is the exploration of these two enzymes as targets for cysteine protease inhibitors that are effective against T. brucei.

PubMed: 20544024
DOI: 10.1371/journal.pntd.0000701

実験手法

X-RAY DIFFRACTION (1.6 Å)