3HHA
Crystal structure of cathepsin L in complex with AZ12878478
Summary for 3HHA
Entry DOI | 10.2210/pdb3hha/pdb |
Descriptor | Cathepsin L1, Nalpha-[(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)carbonyl]-N-[(2Z)-2-iminoethyl]-3-methyl-L-phenylalaninamide, TETRAETHYLENE GLYCOL, ... (7 entities in total) |
Functional Keywords | proteros biostructures gmbh, cathepsin l, inhibitors, disulfide bond, glycoprotein, hydrolase, lysosome, protease, thiol protease, zymogen |
Biological source | Homo sapiens (human) |
Cellular location | Lysosome: P07711 |
Total number of polymer chains | 4 |
Total formula weight | 98676.19 |
Authors | Asaad, N.,Bethel, P.A.,Coulson, M.D.,Dawson, J.,Ford, S.J.,Gerhardt, S.,Grist, M.,Hamlin, G.A.,James, M.J.,Jones, E.V.,Karoutchi, G.I.,Kenny, P.W.,Morley, A.D.,Oldham, K.,Rankine, N.,Ryan, D.,Wells, S.L.,Wood, L.,Augustin, M.,Krapp, S.,Simader, H.,Steinbacher, S. (deposition date: 2009-05-15, release date: 2009-06-23, Last modification date: 2021-10-13) |
Primary citation | Asaad, N.,Bethel, P.A.,Coulson, M.D.,Dawson, J.E.,Ford, S.J.,Gerhardt, S.,Grist, M.,Hamlin, G.A.,James, M.J.,Jones, E.V.,Karoutchi, G.I.,Kenny, P.W.,Morley, A.D.,Oldham, K.,Rankine, N.,Ryan, D.,Wells, S.L.,Wood, L.,Augustin, M.,Krapp, S.,Simader, H.,Steinbacher, S. Dipeptidyl nitrile inhibitors of Cathepsin L. Bioorg.Med.Chem.Lett., 19:4280-4283, 2009 Cited by PubMed: 19515558DOI: 10.1016/j.bmcl.2009.05.071 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.27 Å) |
Structure validation
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