3HHA

Crystal structure of cathepsin L in complex with AZ12878478

3HHA の概要

• エントリーDOI: 10.2210/pdb3hha/pdb
• 分子名称: Cathepsin L1, Nalpha-[(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)carbonyl]-N-[(2Z)-2-iminoethyl]-3-methyl-L-phenylalaninamide, TETRAETHYLENE GLYCOL, ... (7 entities in total)
• 機能のキーワード: proteros biostructures gmbh, cathepsin l, inhibitors, disulfide bond, glycoprotein, hydrolase, lysosome, protease, thiol protease, zymogen
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Lysosome: P07711
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 98676.19

構造登録者

Asaad, N.,Bethel, P.A.,Coulson, M.D.,Dawson, J.,Ford, S.J.,Gerhardt, S.,Grist, M.,Hamlin, G.A.,James, M.J.,Jones, E.V.,Karoutchi, G.I.,Kenny, P.W.,Morley, A.D.,Oldham, K.,Rankine, N.,Ryan, D.,Wells, S.L.,Wood, L.,Augustin, M.,Krapp, S.,Simader, H.,Steinbacher, S. (登録日: 2009-05-15, 公開日: 2009-06-23, 最終更新日: 2021-10-13)

• 主引用文献: Asaad, N.,Bethel, P.A.,Coulson, M.D.,Dawson, J.E.,Ford, S.J.,Gerhardt, S.,Grist, M.,Hamlin, G.A.,James, M.J.,Jones, E.V.,Karoutchi, G.I.,Kenny, P.W.,Morley, A.D.,Oldham, K.,Rankine, N.,Ryan, D.,Wells, S.L.,Wood, L.,Augustin, M.,Krapp, S.,Simader, H.,Steinbacher, S.; Dipeptidyl nitrile inhibitors of Cathepsin L.; Bioorg.Med.Chem.Lett., 19:4280-4283, 2009; PubMed: 19515558; DOI: 10.1016/j.bmcl.2009.05.071

実験手法

X-RAY DIFFRACTION (1.27 Å)