3HFB
Crystal structure of human tryoptophan hydroxylase type 1 with LP-534193
Summary for 3HFB
| Entry DOI | 10.2210/pdb3hfb/pdb |
| Related | 3HF6 3HF8 |
| Descriptor | Tryptophan 5-hydroxylase 1, FE (III) ION, 4-(5-{[(2'-methylbiphenyl-2-yl)methyl]amino}pyrazin-2-yl)-L-phenylalanine, ... (4 entities in total) |
| Functional Keywords | tryptophan hydroxylase type 1, iron, metal-binding, monooxygenase, oxidoreductase, phosphoprotein, serotonin biosynthesis |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 33782.28 |
| Authors | Tari, L.W.,Swanson, R.V.,Hunter, M.J. (deposition date: 2009-05-11, release date: 2010-04-21, Last modification date: 2024-02-21) |
| Primary citation | Cianchetta, G.,Stouch, T.,Yu, W.,Shi, Z.C.,Tari, L.W.,Swanson, R.V.,Hunter, M.J.,Hoffman, I.D.,Liu, Q. Mechanism of Inhibition of Novel Tryptophan Hydroxylase Inhibitors Revealed by Co-crystal Structures and Kinetic Analysis. Curr Chem Genomics, 4:19-26, 2010 Cited by PubMed: 20556201DOI: 10.2174/1875397301004010019 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.92 Å) |
Structure validation
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