3HEI
Ligand Recognition by A-Class Eph Receptors: Crystal Structures of the EphA2 Ligand-Binding Domain and the EphA2/ephrin-A1 Complex
Summary for 3HEI
Entry DOI | 10.2210/pdb3hei/pdb |
Descriptor | Ephrin type-A receptor 2, Ephrin-A1 (3 entities in total) |
Functional Keywords | eph receptor tyrosine kinase, ephrin, cell membrane, disulfide bond, glycoprotein, gpi-anchor, lipoprotein, membrane, atp-binding, kinase, nucleotide-binding, phosphoprotein, receptor, transferase, transmembrane, tyrosine-protein kinase, transferase-signaling protein complex, transferase/signaling protein |
Biological source | Homo sapiens (human) More |
Cellular location | Cell membrane ; Single-pass type I membrane protein : P29317 Cell membrane ; Lipid-anchor, GPI-anchor . Ephrin-A1, secreted form: Secreted : P20827 |
Total number of polymer chains | 16 |
Total formula weight | 286387.29 |
Authors | Himanen, J.P.,Goldgur, Y.,Miao, H.,Myshkin, E.,Guo, H.,Buck, M.,Nguyen, M.,Rajashankar, K.R.,Wang, B.,Nikolov, D.B. (deposition date: 2009-05-08, release date: 2009-06-30, Last modification date: 2021-03-31) |
Primary citation | Himanen, J.P.,Goldgur, Y.,Miao, H.,Myshkin, E.,Guo, H.,Buck, M.,Nguyen, M.,Rajashankar, K.R.,Wang, B.,Nikolov, D.B. Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex. Embo Rep., 10:722-728, 2009 Cited by PubMed: 19525919DOI: 10.1038/embor.2009.91 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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