3HC6

FXR with SRC1 and GSK088

3HC6 の概要

• エントリーDOI: 10.2210/pdb3hc6/pdb
• 関連するPDBエントリー: 3DCT 3DCU 3HC5
• 分子名称: Bile acid receptor, Nuclear receptor coactivator 1, 3-[(5-{[3-(2,6-dichlorophenyl)-5-(1-methylethyl)isoxazol-4-yl]methoxy}-1H-indol-1-yl)methyl]benzoic acid, ... (5 entities in total)
• 機能のキーワード: fxr, nuclear receptor, gw4064, alpha-helical sandwich, activator, alternative splicing, dna-binding, metal-binding, nucleus, receptor, repressor, transcription, transcription regulation, zinc, zinc-finger
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus . Isoform 1: Nucleus . Isoform 2: Nucleus . Isoform 3: Nucleus . Isoform 4: Nucleus : Q96RI1; Nucleus : Q15788
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 30381.46

構造登録者

Williams, S.P.,Madauss, K.P. (登録日: 2009-05-05, 公開日: 2009-07-21, 最終更新日: 2023-09-06)

• 主引用文献: Akwabi-Ameyaw, A.,Bass, J.Y.,Caldwell, R.D.,Caravella, J.A.,Chen, L.,Creech, K.L.,Deaton, D.N.,Madauss, K.P.,Marr, H.B.,McFadyen, R.B.,Miller, A.B.,Navas, F.,Parks, D.J.,Spearing, P.K.,Todd, D.,Williams, S.P.,Bruce Wisely, G.; FXR agonist activity of conformationally constrained analogs of GW 4064.; Bioorg.Med.Chem.Lett., 19:4733-4739, 2009; PubMed: 19586769; DOI: 10.1016/j.bmcl.2009.06.062

実験手法

X-RAY DIFFRACTION (3.2 Å)