3HC6

FXR with SRC1 and GSK088

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
A	0032052	molecular_function	bile acid binding
A	0035076	biological_process	ecdysone receptor signaling pathway
A	0035100	molecular_function	ecdysone binding
A	0038183	biological_process	bile acid signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE 088 A 1

Chain	Residue
A	MET265
A	ARG331
A	SER332
A	HIS447
A	TRP454
A	THR270
A	LEU287
A	THR288
A	MET290
A	ALA291
A	HIS294
A	MET328
A	PHE329

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 473

Chain	Residue
A	LYS275
A	SER279
A	ALA280
A	ASN354

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	224
Details	Domain: {"description":"NR LBD","evidences":[{"source":"PROSITE-ProRule","id":"PRU01189","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PDB","id":"6HL1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by PKC/PRKCZ","evidences":[{"source":"PubMed","id":"18668687","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)","evidences":[{"source":"PubMed","id":"23546875","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Motif: {"description":"LXXLL motif 5"}

Chain

Residue

Details

---