3HBB

Structures of dihydrofolate reductase-thymidylate synthase of Trypanosoma cruzi in the folate-free state and in complex with two antifolate drugs, trimetrexate and methotrexate

Summary for 3HBB

Entry DOI	10.2210/pdb3hbb/pdb
Related	2H2Q 3CL9 3CLB
Descriptor	Dihydrofolate reductase-thymidylate synthase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, TRIMETREXATE, ... (6 entities in total)
Functional Keywords	bifunctional enzyme in complex with nadp and tmq, oxidoreductase, transferase
Biological source	Trypanosoma cruzi
Total number of polymer chains	4
Total formula weight	243506.20
Authors	Schormann, N.,Senkovich, O.,Chattopadhyay, D. (deposition date: 2009-05-04, release date: 2009-05-19, Last modification date: 2023-09-06)
Primary citation	Senkovich, O.,Schormann, N.,Chattopadhyay, D. Structures of dihydrofolate reductase-thymidylate synthase of Trypanosoma cruzi in the folate-free state and in complex with two antifolate drugs, trimetrexate and methotrexate. Acta Crystallogr.,Sect.D, 65:704-716, 2009 Cited by PubMed: 19564691 DOI: 10.1107/S090744490901230X PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation