3HAV

Structure of the streptomycin-ATP-APH(2")-IIa ternary complex

3HAV の概要

• エントリーDOI: 10.2210/pdb3hav/pdb
• 関連するPDBエントリー: 3ham
• 分子名称: Aminoglycoside phosphotransferase, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: aminoglycoside, streptomycin, antibiotic resistance, transferase
• 由来する生物種: Enterococcus faecium (Streptococcus faecium)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 109533.89

構造登録者

Young, P.G.,Baker, E.N.,Vakulenko, S.B.,Smith, C.A. (登録日: 2009-05-02, 公開日: 2009-11-17, 最終更新日: 2023-09-06)

• 主引用文献: Young, P.G.,Walanj, R.,Lakshmi, V.,Byrnes, L.J.,Metcalf, P.,Baker, E.N.,Vakulenko, S.B.,Smith, C.A.; The crystal structures of substrate and nucleotide complexes of Enterococcus faecium aminoglycoside-2''-phosphotransferase-IIa [APH(2'')-IIa] provide insights into substrate selectivity in the APH(2'') subfamily.; J.Bacteriol., 191:4133-4143, 2009; PubMed: 19429619; DOI: 10.1128/JB.00149-09

実験手法

X-RAY DIFFRACTION (2.45 Å)