3H9O

Phosphoinositide-dependent protein kinase 1 (PDK-1) in complex with compound 9

Summary for 3H9O

Entry DOI	10.2210/pdb3h9o/pdb
Descriptor	3-phosphoinositide-dependent protein kinase 1, 2-(1H-imidazol-1-yl)-9-methoxy-8-(2-methoxyethoxy)benzo[c][2,7]naphthyridin-4-amine (3 entities in total)
Functional Keywords	pdk-1, kinase, protein structure, x-ray crysatllography, alternative splicing, atp-binding, cytoplasm, membrane, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: O15530
Total number of polymer chains	1
Total formula weight	35947.16
Authors	Olland, A.M. (deposition date: 2009-04-30, release date: 2009-08-25, Last modification date: 2024-10-30)
Primary citation	Kim, K.H.,Wissner, A.,Floyd, M.B.,Fraser, H.L.,Wang, Y.D.,Dushin, R.G.,Hu, Y.,Olland, A.,Guo, B.,Arndt, K. Benzo[c][2,7]naphthyridines as inhibitors of PDK-1 Bioorg.Med.Chem.Lett., 19:5225-5228, 2009 Cited by PubMed Abstract: A series of substituted benzo[c][2,7]-naphthyridines were prepared and showed good potency in inhibiting PDK-1. The synthesis and SAR of this series of compounds are presented as well as the X-ray crystal structure of one of these analogs in a complex with PDK-1. PubMed: 19628388 DOI: 10.1016/j.bmcl.2009.07.007 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation