3H6U

Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and NS1493 at 1.85 A resolution

3H6U の概要

• エントリーDOI: 10.2210/pdb3h6u/pdb
• 関連するPDBエントリー: 1LBC 3H6T 3H6V 3H6W
• 分子名称: Glutamate receptor 2, GLUTAMIC ACID, (3S)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, ... (7 entities in total)
• 機能のキーワード: ampa receptor ligand-bidning core, iglur2 s1s2j-n754s, allosteric modulation, membrane protein
• 由来する生物種: Rattus norvegicus (rat); 詳細
• 細胞内の位置: Cell membrane; Multi-pass membrane protein: P19491
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30720.02

構造登録者

Hald, H.,Gajhede, M.,Kastrup, J.S. (登録日: 2009-04-24, 公開日: 2009-07-28, 最終更新日: 2023-09-06)

• 主引用文献: Hald, H.,Ahring, P.K.,Timmermann, D.B.,Liljefors, T.,Gajhede, M.,Kastrup, J.S.; Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2.; J.Mol.Biol., 391:906-917, 2009; PubMed: 19591837; DOI: 10.1016/j.jmb.2009.07.002

実験手法

X-RAY DIFFRACTION (1.85 Å)