3H4K
Crystal structure of the wild type Thioredoxin glutatione reductase from Schistosoma mansoni in complex with auranofin
Summary for 3H4K
Entry DOI | 10.2210/pdb3h4k/pdb |
Related | 2v6o |
Descriptor | Thioredoxin glutathione reductase, FLAVIN-ADENINE DINUCLEOTIDE, GOLD ION, ... (7 entities in total) |
Functional Keywords | schistosoma mansoni, gold, auranofin, glutathione, fad, flavoprotein, oxidoreductase, redox-active center |
Biological source | Schistosoma mansoni (Blood fluke) |
Total number of polymer chains | 1 |
Total formula weight | 67219.37 |
Authors | Angelucci, F.,Dimastrogiovanni, D.,Miele, A.E.,Boumis, G.,Brunori, M.,Bellelli, A. (deposition date: 2009-04-20, release date: 2009-08-25, Last modification date: 2023-11-01) |
Primary citation | Angelucci, F.,Sayed, A.A.,Williams, D.L.,Boumis, G.,Brunori, M.,Dimastrogiovanni, D.,Miele, A.E.,Pauly, F.,Bellelli, A. Inhibition of Schistosoma mansoni thioredoxin-glutathione reductase by auranofin: structural and kinetic aspects. J.Biol.Chem., 284:28977-28985, 2009 Cited by PubMed: 19710012DOI: 10.1074/jbc.M109.020701 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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