3H0C

Crystal Structure of Human Dipeptidyl Peptidase IV (CD26) in Complex with a Reversed Amide Inhibitor

Summary for 3H0C

• Entry DOI: 10.2210/pdb3h0c/pdb
• Related: 2BUA 2BUB 2BUC
• Descriptor: Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-beta-D-glucopyranose, N-({(2S)-1-[(3R)-3-amino-4-(3-chlorophenyl)butanoyl]pyrrolidin-2-yl}methyl)-3-(methylsulfonyl)benzamide, ... (4 entities in total)
• Functional Keywords: complex (hydrolase-inhibitor), dpp-iv, diabetes mellitus, drug design, hydrolase, serine protease, aminopeptidase, glycoprotein, protease, signal-anchor, transmembrane, cell membrane, disulfide bond, membrane, secreted
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 171650.91

Authors

Nordhoff, S.,Cerezo-Galvez, S.,Deppe, H.,Hill, O.,Lopez-Canet, M.,Rummey, C.,Thiemann, M.,Matassa, V.G.,Edwards, P.J.,Feurer, A. (deposition date: 2009-04-09, release date: 2009-06-09, Last modification date: 2020-07-29)

• Primary citation: Nordhoff, S.,Cerezo-Galvez, S.,Deppe, H.,Hill, O.,Lopez-Canet, M.,Rummey, C.,Thiemann, M.,Matassa, V.G.,Edwards, P.J.,Feurer, A.; Discovery of b-homophenylalanine based pyrrolidin-2-ylmethyl amides and sulfonamides as highly potent and selective inhibitors of dipeptidyl peptidase IV; To be Published,

Experimental method

X-RAY DIFFRACTION (2.66 Å)